CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata

Transcriptomic profile of tobacco in response to Alternaria longipes and Alternaria alternata infections

Tobacco brown spot caused by Alternaria fungal species is one of the most damaging diseases, and results in significant yield losses. However, little is known about the systematic response of tobacco to this fungal infection. To fill this knowledge gap, de novo assemblies of tobacco leaf transcriptomes were obtained in cultivars V2 and NC89 after the inoculation of either Alternaria longipes (A...

Alternaria alternata serine proteases induce lung inflammation and airway epithelial cell activation via PAR2.

Allergens are diverse proteins from mammals, birds, arthropods, plants, and fungi. Allergens associated with asthma (asthmagens) share a common protease activity that may directly impact respiratory epithelial biology and lead to symptoms of asthma. Alternaria alternata is a strong asthmagen in semiarid regions. We examined the impact of proteases from A. alternata on lung inflammation in vivo ...

The Alternaria alternata Mycotoxin Alternariol Suppresses Lipopolysaccharide-Induced Inflammation

The Alternaria mycotoxins alternariol (AOH) and alternariol monomethyl ether (AME) have been shown to possess genotoxic and cytotoxic properties. In this study, the ability of AOH and AME to modulate innate immunity in the human bronchial epithelial cell line (BEAS-2B) and mouse macrophage cell line (RAW264.7) were investigated. During these studies, it was discovered that AOH and to a lesser e...

Allergic Airway Inflammation CARMA3 Is Critical for the Initiation of

Plant extracts to control Alternaria alternata in Murcott tangor fruits.

BACKGROUND Alternaria alternata causes the Alternaria brown spot disease (ABS) in many tangerines and their hybrids worldwide. Plant extracts offer an alternative method for controlling this disease, which control is based on chemical fungicides. AIMS To identify plant species with antifungal properties against A. alternata, the causal agent of the ABS. METHODS Plant extracts prepared from ...